L-tryptophan induced eosinophilia-myalgia syndrome.

[L-tryptophan and the eosinophilia-myalgia syndrome].

L-tryptophan and eosinophilia-myalgia syndrome.

L-Tryptophan and Eosinophilia-Myalgia Syndrome Participant's Guide Learning Objectives After completing this case study, the participant should be able to: Discuss issues related to rapid establishment of national surveillance for a newly recognized and little understood disorder. Discuss development of case definitions. Describe the elements of design and the advantages and disadvantages of ca...

[Acute respiratory failure as a manifestation of eosinophilia-myalgia syndrome associated with L-tryptophan intake].

Eosinophilia-myalgia syndrome was described in 1989 in patients who presented progressive and incapacitating myalgia and eosinophilia in blood, fluids and secretions. Most patients report previous L-tryptophan intake. Respiratory manifestations are found in up to 80% of the cases, occasionally as the only manifestation. Treatment includes drug discontinuation and administration of corticosteroi...

Acute eosinophilic pulmonary disease associated with the ingestion of L-tryptophan-containing products.

A series of four patients with pulmonary infiltrates, pleural effusions, hypoxemia, peripheral eosinophilia, and symptoms of dyspnea, fatigue, and weakness is reported. Lung tissue obtained in three patients revealed interstitial pneumonitis, small-to-medium-vessel mixed-cell vasculitis, and alveolar exudate of histiocytes and eosinophils. All patients reported ingestion of L-tryptophan-contain...

A murine model of the eosinophilia-myalgia syndrome induced by 1,1'-ethylidenebis (L-tryptophan).

The eosinophilia-myalgia syndrome (EMS) is a recently described disease that has been associated with the ingestion of L-tryptophan containing trace amounts of several impurities. The first such contaminant to be identified and linked epidemiologically to the EMS epidemic was 1,1'-ethylidenebis(L-tryptophan) (EBT), but its role in the etiology and pathogenesis of the syndrome has been controver...